5 RESULTS
COMMENT The cholesterol and statin story in AD has been a never-ending battle since its inception in the late 1980s, and the current paper sends a mixed message. It seems that if the authors exclude the final year of medications from consideration, there is no re
COMMENT I must start by saying that it is quite gratifying that there has been such interest in our clinical trial (AD Cholesterol-Lowering Treatment—ADCLT trial; the Lipitor trial) (1). As the very first AD treatment trial testing a statin medication for clinica
COMMENT This study provides much food for thought and further investigation, though I think the interpretations of the results are a bit narrow. They are predicated on several debatable premises, for example, that the cholesterol pool in the brain is essentially
COMMENT The compelling data by Mauch et al. affirms the critical nature of cholesterol in the CNS, particularly the developing CNS. As with most very good research, the experiments lead to important answers and provide the foundation for more questions. These aut
COMMENT Inflammation, free radicals, and cytokines are involved in a vascular cascade producing the transformation of macrophages into foam cells between the endothelial cell layer and the basement membrane of a blood vessel leading to formation of an atheroscler
